Response to Schistosome Eggs Role of IL-6 in Directing the Initial Immune
نویسندگان
چکیده
منابع مشابه
The Role of Interleukin (IL-22) in immune response to human diseases
Background and aims: IL-22 is an alpha- helical cytokine. IL-22 binds to a heterodimeric cell surface receptor composed of IL-10R2 and IL-22R1subunits. IL-22R is expressed on tissue cells, and it is absent on immune cells. L-22 and IL-10 receptor chains play a role in cellular targeting and signal transduction to selectively initiate and regulate immune responses. The aim of this study was to i...
متن کاملSchistosoma mansoni egg-induced early IL-4 production is dependent upon IL-5 and eosinophils
The initial immune response to Schistosoma mansoni eggs presumably results in IL-4 production, as schistosome eggs are strong Th2-inducing antigens and the differentiation of antigen-specific Th2 cells is largely dependent on the presence of IL-4 during priming of naive Th cells. Consistent with this concept, intraperitoneal injection of mice with schistosome eggs results in an upregulation of ...
متن کاملGr11IL-4-producing innate cells are induced in response to Th2 stimuli and suppress Th1-dependent antibody responses
Alum is used as a vaccine adjuvant and induces Th2 responses and Th2-driven antibody isotype production against co-injected antigens. Alum also promotes the appearance in the spleen of Gr11 IL-41 innate cells that, via IL-4 production, induce MHC II-mediated signaling in B cells. To investigate whether these Gr11 cells accumulate in the spleen in response to other Th2-inducing stimuli and to un...
متن کاملConcurrent bacterial stimulation alters the function of helminth-activated dendritic cells, resulting in IL-17 induction.
Infection with schistosome helminths is associated with granulomatous inflammation that forms around parasite eggs trapped in host tissues. In severe cases, the resulting fibrosis can lead to organ failure, portal hypertension, and fatal bleeding. Murine studies identified IL-17 as a critical mediator of this immunopathology, and mouse strains that produce high levels of IL-17 in response to sc...
متن کاملبررسی نقش سلو لهای دندریتیک کبد و طحال در القای پاس خهای سلولی 1 TH و 2 TH
Background & Objective: Dendritic cells(DCs) play an important role in directing immune response toward TH1(T-Helper 1) or TH2(T-Helper 2). These cells may induce distinct cytokine patterns in different tissues. So the pattern of cytokine induction by liver and spleen DCs may differ from each other. To investigate the difference between immune responses in the liver(as a non-lymphoid organ ...
متن کامل